When Does Parkinson Disease Start?

When does Parkinson disease start?

There is convincing evidence that the Parkinson disease neurodegenerative process begins many years before the onset of motor manifestations. Initial estimates based on nigral neuropathological findings or striatal dopamine imaging suggested a 5- to 6-year preclinical period. However, more recent evidence of Lewy body pathology in other neuronal populations preceding nigral involvement suggests...

Alzheimer ' s disease : When does personality start to change ?

Parkinsonian features: when are they Parkinson disease?

Parkinsonian syndromes can be classified into 2 major groups: Parkinson disease (PD)andatypicalparkinsoniandisorders. Commoncharacteristics includeakinesia, expressed as slowness and paucity of movement (eg, decreased arm swing or facial expression) and difficulty in initiating movement, and are associated with rigidity with or without resting tremor. Parkinsonian syndromes frequently occur in ...

Does this patient have Parkinson disease?

CONTEXT Diagnosis of Parkinson disease (PD) remains challenging. An accurate diagnosis is important because effective symptomatic treatment for PD is available. OBJECTIVE To systematically review the literature for information on the precision and accuracy of the clinical examination for diagnosing PD. DATA SOURCES MEDLINE database was searched for all English-language articles related to t...

Does HIV Infection Alter Parkinson Disease?

OBJECTIVE To describe the clinical features, treatment(s), and outcomes of 15 HIV-infected patients with idiopathic Parkinson disease (PD) and sustained virus suppression and immunologic reconstitution, from a reference cohort of 9847 persons living with HIV (PLH). METHODS This retrospective, single-center matched case-control 1:2 study included PLH-PD patients evaluated over a 12-year period...